As an aggressive tumor type of ovarian cancer, HGSOC had a higher relapse rate (~25%) and poorer overall 5-year survival rate (31%). Serous ovarian cancer is a gynecological tumor that is more common in women, and high-grade serous ovarian cancer (HGSOC) accounts for roughly 70% of ovarian cancer deaths. It is possible to generate novel potential targeted therapy strategy and translational application for serous ovarian carcinoma patients with a predictable better clinical outcome. Together, these results revealed that CtBP1/2 play a different regulatory role in genomic stability and DSBs repair pathway bias in serous ovarian cancer cells. Interesting, blast through TCGA tumor cases, patients with CtBP2 genetic alternation had a significantly longer overall survival time than unaltered patients. Furthermore, CtBP1/2 knockdown shifted the DSBs repair pathway from homologous recombination (HR) to non-homologous end joining (NHEJ) and activated DNA-PK in SKOV3 cells. CtBP1 protects the integrity of stalled forks under metabolic stress condition during prolonged periods of replication, whereas CtBP2 acts a dominant role in stability of DNA replication recovery. The results of DNA fiber assay revealed that CtBP1/2 contribute differentially to the integrity of DNA replication track and stability of DNA replication recovery. CtBP1/2 knockdown induced cancer cell apoptosis, increased genetic instability, and enhanced the sensitivity to DNA damage agents, such as γ-irradiation and chemotherapy drug (Carboplatin and etoposide). Several key functional pathways were significantly enriched through whole transcription profile analysis of CtBP1/2 knockdown SKOV3 cells, including DNA damage repair, apoptosis, and cell cycle. In this study, we combined whole-transcriptome analysis with multiple research methods to investigate the role of CtBP1/2 in genomic stability. However, little is known about CtBP proteins’ regulatory roles in genomic stability and DNA repair in HGSOC. CtBP proteins were identified with overexpression in the high-grade serous ovarian carcinoma (HGSOC). Recommended.” (Pediatric Endocrinology Reviews, Vol.The C-terminal binding proteins (CtBPs), CtBP1 and CtBP2, are transcriptional co-repressor that interacts with multiple transcriptional factors to modulate the stability of chromatin. … Mainly, but not only, for neurobiologists, psychologists and psychiatrists. “The book has 20 chapters divided into 6 parts. Jellinger, European Journal of Neurology, Vol. It is therefore recommended to all clinicians and neuroscientist who are interested and engaged in the complex field of ASDs.” (K. the present book provides an impressive, evidence-based review of pathogenesis, clinical features, genetics, biological bases, pathogenetic factors, current or future treatments of ASDs. “All chapters are uniformely arranged with initial abstract, many informative subheadings, tables and impressive figures. Munson, The New England Journal of Medicine, Vol. … this book is a valuable contribution to the effort to map autism, and it is a demonstration of the type of cooperation that is needed across scientific disciplines if progress is to be made in this effort." (Jeffrey A. "Autism: Current Theories and Evidence, edited by Andrew Zimmerman, serves as an atlas or geophysical study of the archipelago of autism. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics Neurotransmitters and Cell Signaling Endocrinology, Growth and Metabolism Immunology, Maternal-Fetal Effects and Neuroinflammation Neuroanatomy, Imaging and Neural networks and Environmental Mechanisms and Models. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories.
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